1+ day, 9+ hour ago   (521+ words) Bacteria are famous for forming patterns, from the concentric rings of Proteus colonies to the branching networks that motile microbes paint across agar plates. Now researchers at Columbia University have turned one of biology’s most familiar workhorses, Escherichia coli, into…...

1+ day, 10+ hour ago   (625+ words) A team of researchers at Sun Yat-Sen University Cancer Center has unveiled a new computational framework that captures how tumor-infiltrating myeloid cells change their functional identities across many types of cancer....

1+ day, 11+ hour ago   (661+ words) A single protein called BAX sits at the gateway between life and death for human cells. When tissues are injured, stressed, or deprived of oxygen, BAX springs into action, punching holes in the outer membrane of mitochondria and triggering the…...

1+ day, 12+ hour ago   (485+ words) A sprawling review of the meadow rue genus, Thalictrum, has catalogued a striking trove of biologically active plant chemicals across Africa and Asia, while simultaneously exposing how little of the evidence stands up to rigorous scientific scrutiny....

1+ day, 12+ hour ago   (55+ words) Pembrolizumab, one of the most widely prescribed cancer immunotherapies in the world, has long been dosed on the assumption that saturating the PD-1 receptor on T cells is the key to unlocking the immune system against tumours. A new translational…...

1+ day, 12+ hour ago   (120+ words) Adoptive T cell therapy has delivered striking remissions in some blood cancers, but its promise in solid tumors has been repeatedly undermined by a stubborn problem: the therapeutic cells do not last. Engineered T cells that flood a tumor and…...

1+ day, 12+ hour ago   (704+ words) Cardiovascular medicine is quietly undergoing a structural rethink, and the change begins with the order of operations....

1+ day, 12+ hour ago   (55+ words) Gene editing has long promised a revolution in cancer medicine, yet the promise has remained stubbornly out of reach for one deceptively simple reason: getting the CRISPR-Cas9 machinery into tumor cells, and only tumor cells, is extraordinarily difficult. A new…...

1+ day, 12+ hour ago   (534+ words) Mapping the wiring of the brain at nanometer resolution has long demanded a punishing trade-off: electron microscopy can reveal every synaptic cleft and organelle, but imaging even a cubic millimeter of neural tissue this way takes months or years of…...

1+ day, 12+ hour ago   (580+ words) A rare and devastating form of autoimmune encephalitis has long puzzled neurologists: patients develop severe sleep disturbances, breathing difficulties, and progressive movement and cognitive problems, yet the underlying attack on the brain remained poorly understood at the molecular level....