1+ day, 1+ hour ago   (55+ words) Pembrolizumab, one of the most widely prescribed cancer immunotherapies in the world, has long been dosed on the assumption that saturating the PD-1 receptor on T cells is the key to unlocking the immune system against tumours. A new translational…...

1+ day, 1+ hour ago   (120+ words) Adoptive T cell therapy has delivered striking remissions in some blood cancers, but its promise in solid tumors has been repeatedly undermined by a stubborn problem: the therapeutic cells do not last. Engineered T cells that flood a tumor and…...

1+ day, 1+ hour ago   (704+ words) Cardiovascular medicine is quietly undergoing a structural rethink, and the change begins with the order of operations....

1+ day, 4+ hour ago   (653+ words) A new study comparing the two main ways of freezing human sperm has found that even when samples look equally healthy under the microscope, the proteins inside them tell a strikingly different story....

1+ day, 7+ hour ago   (746+ words) A sweeping new review published in Discover Chemistry charts the remarkable rise of proteolysis-targeting chimeras, better known as PROTACs, from a bold theoretical idea to one of the most closely watched platforms in modern drug discovery. Written by Sandip G....

1+ day, 8+ hour ago   (75+ words) Bladder urothelial carcinoma remains one of the most challenging malignancies in oncology, a disease whose treatment has been persistently undermined by its remarkable ability to shrug off chemotherapy. Now, a team of researchers in China has uncovered a molecular mechanism…...

1+ day, 8+ hour ago   (734+ words) Pathology is undergoing a quiet revolution, and a new study published in Nature Cancer may accelerate it dramatically....

1+ day, 10+ hour ago   (90+ words) For decades, the vast stretches of the human genome that do not encode proteins were dismissed as evolutionary baggage, a biological wasteland dismissed with the shorthand of “junk DNA.” A comprehensive new review published in Nature Reviews Gastroenterology & Hepatology makes…...

1+ day, 16+ hour ago   (102+ words) Interventional oncology stands at a decisive moment in its history, and one of its most distinguished voices has now mapped out exactly where the field must go by the end of the decade. In the inaugural Thierry de Baère Lecture,…...

1+ day, 23+ hour ago   (754+ words) Precision medicine has long promised a future in which a patient’s treatment is tailored to the molecular signatures written into their genome, transcriptome, epigenome, proteome and metabolome....